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the Essential Value


We add value of your understanding of regulatory guidance on


Impurity

Extractables and Leachables

CCIT (Container closure Integrity testing)


Also, Saint-Gobain with Tubing and Bag as Single use system

SWISS BASEL, E&L SCHOOL Welcome KOREA CUSTOMER

🌐 Quality by Design Inc. - Your Trusted Partner in E&L Studies 🌐

At Quality by Design Inc., we pride ourselves on being at the forefront of the Extractables and Leachables (E&L) study landscape. Our comprehensive services cover:


🔍 Consultation on the current E&L study approach 

🔬 Critical assessment and evaluation 

📜 Extractables & Leachables study and profiling 

🧪 Identification & Toxicological evaluations 

🛡️ Risk and Safety assessments 

✅ Regulatory Registration support


Key Areas of Expertise:

  • Container closure systems like glass vials, stoppers, and related products.
  • Single-use systems and process contact materials.
  • All types of Medical Devices.

"We proudly showcase our global regulatory expertise, with a track record of obtaining product approvals across:

  • FDA, EMA, CHINA, KOREA, JAPAN, BRASIL, Türkiye(Turkey) and more.

Have an inquiry or need expert advice? 📩 Reach out to us at qbd@qbd.co.kr

For a more in-depth look at what we offer, visit our official website at www.qbd.co.kr

Let's navigate the complexities of E&L together! We look forward to partnering with you. 💼🌟


E&L and Pharmaceutical Regulatory Compliance AI 

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큐비디 리뷰의견BPOG - GUIDE TO THE EXTRACTABLES TEST REPORT (APRIL 2020)

관리자
2024-04-08
조회수 1065

Guide to creating a BioPhorum Extractables Test Reports


Title page

The title page should include:

  • Report title, study identity, report date, report revision
  • Name and location of lab performing the testing and name and location of sponsor, if applicable
  • Signatures

Study summary

The Study summary for SUS components tested should consist of:

  • Short description of background of testing
  • Short description of the testing setup and experimental part
  • Short summary of results and conclusion

Study design

Outline of the study design information must follow the BioPhorum Extractables Data Summary (BEDS) spreadsheet template. It includes information on:

  • Test article traceability
  • Pre-treatment(s) of the test article
  • Extraction conditions, solvents and time points
  • Analytical information
  • Supporting information on the test item

Summary tables

One summary table for organic compounds and one summary table for elements should be included in the report. The formats of the summary tables must follow the BEDS

spreadsheet template. In addition to including the summary tables in the Extractables Test Report, the summary tables need to be made available in BEDS spreadsheet format. It is optional to report structures of identified compounds.

Results from analyses

Results from each individual analysis technique should be reported separately. It is highly recommended, but not mandatory, to follow the format provided in the BEDS spreadsheet template.


 

Analytical methods

Information on each individual analysis technique should be reported separately. It is highly recommended, but not mandatory, to follow the format provided in the BEDS spreadsheet template. Information on analytical methods shall include:

  • Method traceability
  • Instrument settings
  • Method qualification
  • System suitability test (SST)
  • Sample preparation
  • Approaches for quantification and identification

Deviations

Any deviations observed during the study needs to be documented.

Terminology

Acronyms used in the Extractables Test Report need to be explained.

Revision history

Revision history of the report needs to be included, describing changes made to the Extractables Test Report after initial release.

The final reporting should be within the oversight of the company’s quality management system and can be in one of the following formats (or a combination):












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