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We provide 

the Essential Value


We add value of your understanding of regulatory guidance on


Impurity

Extractables and Leachables

CCIT (Container closure Integrity testing)


Also, Saint-Gobain with Tubing and Bag as Single use system

SWISS BASEL, E&L SCHOOL Welcome KOREA CUSTOMER

🌐 Quality by Design Inc. - Your Trusted Partner in E&L Studies 🌐

At Quality by Design Inc., we pride ourselves on being at the forefront of the Extractables and Leachables (E&L) study landscape. Our comprehensive services cover:


🔍 Consultation on the current E&L study approach 

🔬 Critical assessment and evaluation 

📜 Extractables & Leachables study and profiling 

🧪 Identification & Toxicological evaluations 

🛡️ Risk and Safety assessments 

✅ Regulatory Registration support


Key Areas of Expertise:

  • Container closure systems like glass vials, stoppers, and related products.
  • Single-use systems and process contact materials.
  • All types of Medical Devices.

"We proudly showcase our global regulatory expertise, with a track record of obtaining product approvals across:

  • FDA, EMA, CHINA, KOREA, JAPAN, BRASIL, Türkiye(Turkey) and more.

Have an inquiry or need expert advice? 📩 Reach out to us at qbd@qbd.co.kr

For a more in-depth look at what we offer, visit our official website at www.qbd.co.kr

Let's navigate the complexities of E&L together! We look forward to partnering with you. 💼🌟


E&L and Pharmaceutical Regulatory Compliance AI 

의약품 인허가 관련 질문하시고 간단한 답변 받으실 수 있습니다.


큐비디 SERVICE ITEMVISIBLE PARTICULATE MATTER (Quality Considerations for Topical Ophthalmic Drug Products Guidance for Industry)

관리자
2024-05-27
조회수 745

III.      VISIBLE PARTICULATE MATTER


 The use of a robust visual inspection program and the implementation of CGMP requirements are important to ensure products are not adulterated. For topical ophthalmic drug products packaged in opaque containers, appropriate technologies (e.g., X-ray spectroscopy) or destructive testing should be used to identify particulates within the accepted visible size range.[21]


Ophthalmic drug products with names recognized in the USP are generally required to also meet  the particulate matter requirements in USP General Chapter <771> Ophthalmic Products—Quality Tests.[22] Noncompendial ophthalmic drug products should also follow the above USP General Chapter. Adherence to compendial standards can assist applicants and manufacturers in complying with CGMP regulations (e.g., 21 CFR 211.165(e), 211.167(b), and 211.194(a)(2)).


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[21] For topical ophthalmic drug products that include inherent visible particulates by design, such as suspensions and 

emulsions, stability testing can be used to evaluate any changes in the particle size over the shelf life of the product. 

See USP General Chapter <771> Ophthalmic Products—Quality Tests.


[22] See section 501(b) of the FD&C Act.

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